![]() Like natural glycan-binding proteins, these receptors bind pyranosides by accessing multivalent and cooperative interactions, and these studies suggest a new approach towards biomimetic synthetic carbohydrate receptors, where conformational flexibility and promiscuity are incorporated into design. The first-principles modelling suggests that 10⋅β-Man forms an inclusion-type complex where the glycan engages both monomeric subunits of 10 through H-bonding and C−H⋅⋅⋅π interactions. Program in Chemistry, Graduate Center of the City University of New York, 10016 New York, NY, USA Co-first authors these authors contributed equally to the manuscript. A variety of 1D and 2D NMR, and computational techniques were used to determine the thermodynamic binding parameters (Δ H o and Δ S o) and the structure of the host–guest complex, revealing that dimeric receptor 10 binds β-Man with increased enthalpy, but a larger entropic penalty than 1. Hunter College of the City University of New York, 695 Park Avenue, 10065 New York, NY, USA Ph.D. Although the receptors are promiscuous, 1 shows selectivity for β-Man at a ratio of 103:1 β-Man:β-Gal, receptors 2– 4 and 6 have preference for α-Man, 5 is selective for β-Gal, and 10 prefers α-Glc (Man=mannose Gal=galactose, Glc=glucose). Herein the binding of 8 receptors with 5 distinct octyloxy pyranosides, which was measured by mass spectrometry and by 1H NMR titrations in CD 2Cl 2 at 298 K, is reported, providing binding affinities that vary from ≈10 1–10 4 m −1. #Wiley online library hunter college pdfLog in Purchase Instant Access 48-Hour Online Access 7.00 Details Online-only access 16.00 Details PDF download and online access 42.00 Details Check out No abstract is available for this article. ![]() Synthetic carbohydrate receptors could serve as agents for disease detection, drug delivery, or even therapeutics, however, they are rarely used for these applications because they bind weakly and with a preference towards the all-equatorial glucosides that are not prevalent on the cell surface. Access through your institution Log in to Wiley Online Library If you have previously obtained access with your personal account, please log in. We discuss the pioneering Age-Friendly University (AFU) initiative that takes a systems-level approach and offers guiding principles for advancing age inclusivity, which in turn can combat and inoculate individuals against ageism. ![]()
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